Advantages:
There is a complete production line. Stable and high-quality raw material sources. Mature and stable production process. The product solvent residue is qualified. A variety of product specifications are available. It can be stored for a long time in a cool, dry place and sealed away from light.
Product function and use
Efficacy and use
Baicalin (Baicalin) is a flavonoid compound extracted and isolated from the root of Scutellaria baicalensis. It has significant biological activity, has antibacterial, diuretic, anti-inflammatory, anti-allergic and antispasmodic effects, and has strong anti-cancer effects. Physiological effects such as response. It has occupied an important position in clinical medicine. Baicalin can also absorb ultraviolet rays, scavenge oxygen free radicals, and inhibit the production of melanin. Therefore, it can be used in both medicine and cosmetics. It is a good raw material for functional beauty cosmetics.
Pharmacological effects
1. Anti-tumor effect:
In vitro, baicalin has a significant inhibitory effect on the proliferation of S180 and Hep-A-22 tumor cells. As the drug concentration increases, the inhibitory effect gradually increases, and the survival days of Hep-A-22 mice are significantly prolonged.
2. Anti-pathogen effect:
Baicalin has a wide antibacterial range and has strong effects on Staphylococcus aureus and Pseudomonas aeruginosa. Sun Dongmei et al. conducted antibacterial tests on drug-resistant Staphylococcus aureus in vitro and on mice infected with drug-resistant Staphylococcus aureus in vivo. Protective effect, observe the antibacterial effect of baicalin. The minimum inhibitory concentrations of baicalin and compound sulfamethoxazole (SMZ-TMP) against drug-resistant Staphylococcus aureus are 2 mg/ml and 0.45 mg/ml respectively. In vivo experiments show that baicalin (100 mg/kg) can reduce The mortality rate of mice infected with drug-resistant Staphylococcus aureus indicates that baicalin has an antibacterial effect on drug-resistant Staphylococcus aureus.
3. Protective effect against liver damage:
Use CCl4 and D-galactose to make a mouse acute liver injury model, and use colorimetric analysis to measure the activities of mouse serum aspartate aminotransferase and alanine aminotransferase; measure mouse serum superoxide dismutase and glutathione Peptide peroxidase activity and malondialdehyde content. Results Baicalin can significantly reduce the increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in mice with acute liver injury caused by CCl4 and D-galactose; The activities of oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) are significantly increased, and the content of malondialdehyde (MDA) is reduced. The results showed that baicalin had a protective effect on acute liver injury in mice induced by CCl4 and D-galactose. In the experiment, SOD and GSH-Px in the administration group were significantly higher than those in the model group, while MDA content was significantly lower, indicating that the hepatoprotective mechanism of baicalin is closely related to its resistance to free radical lipid peroxidation.
4. Improvement of diabetic nephropathy:
Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus (DM), and research on its pathogenesis has always been a hot topic in the field of diabetes at home and abroad. Hyperglycemia is the initiating factor that causes diabetic nephropathy, and through a series of processes in the body, it can cause oxidative stress and inflammatory reactions inside the body, leading to the activation of the local cytokine network in the kidney and leading to DN. During the entire process, the renin-angiotensin system plays an important role, among which angiotensin II (Ang II) is the most active factor in this system and is most closely related to DN. After baicalin treatment, AngII was significantly restored, which is the target of baicalin's protection of renal function in DN rats. That is, baicalin treats or protects DN by reducing the activity of the renin-angiotensin system (RAS) under hyperglycemia. Renal function in rats. In addition, baicalin can also restore kidney function by reducing blood pressure and intraglomerular pressure, improving blood internal environment and circulatory function after reducing AngII.
5. Repair and protective effects on brain damage:
Hu Xiumei used the suture embolization method to establish a model of focal cerebral ischemia-reperfusion injury caused by middle cerebral artery occlusion in rats, and observed the effects of baicalin on the behavioral scores, cerebral infarction rate, brain water content, and brain tissue NO, The influence of NOS, MDA and SOD. It was found that baicalin can significantly improve the behavioral disorders caused by cerebral ischemia-reperfusion in rats, reduce the infarction rate, reduce the water content of brain tissue, and significantly reduce the content of NO and the activity of NOS in the brain tissue, thereby reducing the neurological effects of NO. Cytotoxicity. At the same time, baicalin can reduce the content of MDA in the brain tissue of ischemia-reperfusion rats and increase the activity of SOD, thereby inhibiting lipid peroxidation caused by free radicals and reducing the damage of free radicals to brain tissue. Baicalin has a significant protective effect on cerebral ischemia-reperfusion injury in rats, which may be related to its antioxidant effect in the early stage of cerebral ischemia-reperfusion. At the same time, baicalin has protective and repairing effects on learning and memory function impairment in cerebral ischemia-reperfusion model mice.
6. Impact on retinopathy:
Song Haogang et al. established an animal model of inflammatory retinal edema, used optical coherence tomography (OCT) to continuously observe the changes in the thickness of inflammatory retinal edema, and compared it with the results of retinal morphology observation and retinal thickness measurement. From the imaging and histology The effect of baicalin in inhibiting retinal inflammatory edema was quantified, and the effects of different concentrations of the drug were evaluated. Baicalin has a significant inhibitory effect on retinal extracellular inflammatory edema and is no less effective than topical corticosteroids.
7. Anti-allergic reaction:
The reaction structure of baicalin is the same as that of the desensitizing drug cromoglycate disodium, so its anti-allergic effects are also similar.
Storage :
Store in a cool, dry, dark, and high-temperature place.
Packaging :
Negotiate or use double layer plastic bags internally, 1kg aluminum foil bags, 25kg drum.
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