What is Liposomal Quercetin?
Liposomes are vesicles composed of lipid components such as phospholipids and have a similar biological membrane structure. Lecithin is generally derived from natural lecithin, and the most common ones are soybean lecithin and egg yolk lecithin. After further processing, these lecithins can be made into liposomes for encapsulating quercetin.
By encapsulating quercetin in liposomes, the stability, solubility and bioavailability of quercetin can be improved, making it have better application prospects in the fields of medicine and health products.
What are the differences between liposomal quercetin and quercetin?
Quercetin: It is a natural flavonoid compound with a specific molecular structure. It exists in plants in a free form or in the form of glycosides combined with sugars.
Liposomal quercetin: It is a new preparation formed by encapsulating quercetin inside liposomes. Liposomes are vesicle structures composed of phospholipid bilayers, in which quercetin is encapsulated, forming a complex similar to a cell structure.
Physical and chemical properties
Quercetin: It is insoluble in water, has limited solubility in organic solvents, and has poor stability, especially under conditions of light, high temperature, high humidity, etc., it is prone to oxidation, degradation and other reactions.
Liposomal quercetin: Due to being encapsulated by liposomes, its solubility and stability have been significantly improved. The phospholipid bilayer structure of liposomes can protect quercetin from the influence of the external environment, while making it more dispersible in water, showing properties similar to colloidal solutions.
Bioavailability
Quercetin: After oral administration, its bioavailability is low due to its low solubility and easy metabolism in the gastrointestinal tract. Most quercetin may be metabolized by intestinal flora or excreted with feces before absorption, and the amount that can actually enter the blood circulation and play a role is small.
Liposomal quercetin: The presence of liposomes helps to improve the bioavailability of quercetin. Liposomes can interact with cell membranes and enter cells more easily through endocytosis or fusion, thereby promoting the absorption of quercetin. In addition, liposomes can also protect quercetin from being metabolized prematurely in the gastrointestinal tract, allowing it to reach the site of action more effectively.
Efficacy
Quercetin: It has multiple biological activities such as antioxidant, anti-inflammatory, and anti-tumor, but due to its low bioavailability and poor stability, its efficacy is limited to a certain extent.
Liposomal quercetin: It can better exert the efficacy of quercetin. On the one hand, the improved bioavailability allows more quercetin to reach target cells and target organs; on the other hand, the targeting of liposomes allows quercetin to act more concentratedly on the lesion site, thereby enhancing its therapeutic effect. For example, in anti-tumor research, liposomal quercetin can more effectively enter tumor cells, play a role in inducing tumor cell apoptosis and inhibiting tumor growth.
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