Iron is one of the essential trace elements of the human body, which is involved in the transport of oxygen in the body and the process of tissue respiration to maintain the normal hematopoietic function of the body. Iron deficiency reduces the synthesis of hemoglobin and leads to anemia, known as iron deficiency anemia (IDA).
Summarize
Ferrous glycine is an amino acid chelated iron and has properties not found in other irons. The high bioavailability of ferrous glycine is due to the fact that it is small enough and highly stable to pass intact through the mucous membrane of the digestive tract. Other forms of iron must be digested or dissociated in the body before being absorbed, and ionic forms of iron cause harmful gastrointestinal side effects such as constipation and acute abdominal pain, while ferrous glycine does not.
Characteristics of ferrous glycine
1. High bioavailability
The bioavailability of glycine is significantly superior to that of any other form of iron agent. The bioavailability of common iron compounds is affected by various absorption inhibitors, such as phytates, fibers, tannins, etc.
Ferrous glycine can overcome these obstacles and ensure its complete absorption. One study demonstrated that even in the presence of the same inhibitor, ferrous glycine absorption is 4.5 times higher than ferrous sulfate, and this excellent bioavailability of ferrous glycine makes it a third generation of new compounds in iron nutrition additives.
The body absorbs amino acids so efficiently that they rank first in the order in which nutrients pass through the intestinal wall after digestion, and in fact 95% of all amino acids are absorbed. Iron chelates with amino acids so that it is carried as a compound through the intestinal wall during transport.
2.Excellent physiological effects
Ferrous glycine is not only effective in correcting the body's hematopoietic needs, but also has a good effect on rebuilding the body's iron. In addition, it does not produce the usual side effects of ferrous sulfate. When iron is used as an additive, bioavailability and tolerance are the two most important factors. Ferrous glycine is obviously superior to ferrous sulfate and other iron nutrient additives in both aspects.
3. The neutral character of ferrous glycine palliative effect (very comfortable for organ systems, good safety)
Chelation results in the final mineral compound becoming electrically neutral. For example, ferrous sulfate is acid-broken down in the stomach to form positively charged free iron metal ions, which can bind to any negatively charged substance in their free state. Phytic acid and free phosphoric acid groups from plants are two common substances found in the stomach and intestines that can lock free ions in for a long time, making it completely unusable.
Because of its stability and electrical neutrality, chelated ferrous glycine can be transported to the absorption site of the jejunum intact. Thus unlike ferrous iron, which comes from soluble salts, absorption depends on pH and is mainly absorbed in the duodenum; Ferrous glycine contacts a larger area of the intestinal mucosal surface, significantly increasing the efficiency of its absorption.
Ferrous glycine is dissociated in the gastric acid of the stomach, adsorbed to mucosal membranes or catalyzed by an enzyme, and after entering the plasma, it continues to enter the tissues intact, and at the cellular level of the tissues, it enters an enzyme system as it crosses microorgan membranes in cells or enters from one cell to another, where it is degraded due to an altered stability constant. The released atoms then bind to the more stable transferrin and are transported to the blood in the small intestine capillaries.
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