1. Anti-oxidation, anti-free radical effect
The activity of flavonoids against lipid peroxides has been confirmed in the 1960s, because the polyhydroxyl structure of many flavonoids can be chelated with metal ions and have significant antioxidant properties, so it is believed that it acts as an antioxidant.
Phloretin has a strong antioxidant, the antioxidant concentration of oil between 10-30PPm, can remove free radicals in the skin, and free radicals are produced by the oxidation reaction harmful substances to the body, related to human degenerative diseases, external use can prevent sugar components into the epidermal cells, thereby inhibiting the excessive secretion of skin glands, the treatment of secretion of acne and so on.
Studies have shown that phloretin can inhibit melanocyte activity and dilute various skin stains. It has a good inhibitory effect on tyrosinase and is a very safe and effective whitening agent for freckle removal. Phloretin has a very good moisturizing effect, can absorb 4 to 5 times its own weight of water.
2. Strong water absorption
Phloretin is a very safe and effective transdermal osmotic agent, which can promote the absorption and utilization of other functional factors in the formula, so that it can play a better effect. Phloretin has a good LOX inhibition effect, so phloretin is also a good anti-hair loss agent.
3. Anti-inflammatory and immunosuppressive effects
Studies have shown that the occurrence of inflammation is related to NO, NO is catalyzed by NO synthase synthesis, and excessive NO in pathological state is catalyzed by induced NO synthase production. Under the influence of phloretin, the NO release of macrophages decreased significantly under the stimulation of LPS and IFN-γ inhibition. The phagocytosis rate of megalithic cells also decreased significantly under the action of phloretin. Thus phloretin has a potential anti-inflammatory effect. In terms of immunosuppression, phloretin is a known competitive inhibitor of the sodium D-glucose cotransporter.
Because it can increase the fluidity of the lipid bilayer in the cell, it can play a role in increasing the type and activity of drugs delivered across the skin membrane.
4. Anti-tumor and anticancer effects
T cells are inherent immune T cells that are widely present in mucosal and epithelial tissues of digestive system, respiratory system, etc. Their anti-tumor effects are similar to some functional features of αβT cells. There are also antigens that do not require MHC molecule presentation, directly recognize proteins and peptide antigens, non-peptide antigens, have the function of antigen extraction, and can play an immunomodulatory role through cell contact and secretion of cytokines.
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