Oleanolic Acid CAS: 508-02-1 Hemsleya Chinensis Extract Antibiotics Antiphlogosis

• CAS No.: 508-02-1
• Formula: C30h48o3
• EINECS: 208-081-6
• Type: Oleanolic Acid
• Nutritional Value: Nutritional
• Effect: Antibiotics Antiphlogosis
• Model NO.: >98%
• Resource: Natural
• Transport Package: Drum/Carton/Bag
• Specification: Oleanolic acid 98%
• Trademark: QINGYA
• Origin: China
• HS Code: 1302199099
• Production Capacity: 100kg/Months

Product Description

Product physical and chemical properties

Product Name: Oleanolic acid

CAS:508-02-1

Molecular formula: C30H48O3

Molecular weight:456.70

Product specifications:5%- 98%

Detection method: HPLC

Density: 1.1g/cm³

Melting point: >300 ºC(lit.)

Boiling point:553.5 ºC at 760 mmHg

Flash point: 302.6 ºC

Refractive index:1.557

Physical properties: White powder

Stability: Stable at normal temperatures and pressures.(2-8ºC)

Solubility: Almost insoluble in water, slightly soluble in ethanol and chloroform.

 

English alias:
Olean-12-en-28-oic acid, 3-hydroxy-, (3β)-; Oleanol;  CARYOPHYLLIN;  Oleanic acid

Extraction source:
The root tuber of hemsleya macrosperma c.y.w, hemsleya amabilis diels and hemsleya chinensis cogn.

Application Status
Oleanolic acid is a broad spectrum antibacterial drug, which is used in the treatment of bronchitis, pneumonia, acute tonsillitis, periodontitis, bacillary dysentery, acute gastroenteritis and urinary system infection. In addition, it is also used to treat acute hepatitis.

 

Pharmacological effect
1. Reduce liver damage:
Oleanolic acid is a pentacyclic triterpenoid compound, which has obvious protective effect on acute and chronic liver injury caused by carbon tetrachloride in rats. After treatment, enlarged mitochondria and enlarged rough endoplasmic reticulum were restored. The ballooning degeneration, necrosis and inflammatory reaction of hepatocytes in acute and chronic liver injury can be significantly reduced. The accumulation of triglycerides in the liver decreased and the amount of glycogen increased.
2. Decreased serum alanine aminotransferase activity:
Oleanolic acid can significantly reduce enzymes in acute and chronic hepatitis and liver cirrhosis animals.
3. Decreased serum R-globulin and was consistent with the reduction of liver-related inflammatory response seen in histological observations.
4. Promotes liver cell regeneration:
Oleanolic acid can significantly increase the number of mitotic phases in the residual liver of rats, and the regeneration degree is higher than that of the control group, suggesting that oleanolic acid can promote cell regeneration.
5. Reduce the level of cooline in the brain homogenate of cirrhotic rats:
Because the level of cooline in brain homogenate decreased obviously, it could inhibit the production of false neurotransmitter, so it was beneficial to the prevention and treatment of hepatic encephalopathy.
6. Inhibit hepatic fiber hyperplasia:
After oleanolic acid treatment, the liver fibrosis of rats was seriously and significantly reduced, and the content of liver collagen was reduced, suggesting that it has the effect of prevention and treatment of liver cirrhosis.
Seven. Oleanolic acid can significantly inhibit mononuclear phagocyte system, macrophage phagocytosis and experimental arthritis in mice, but it can affect the humoral immune function of opposite sex and antigen-binding cells. Enhance immunity and inhibit the growth of S180 tumor strain.
8. It has a protective effect on chromosome damage, a preventive effect on experimental atherosclerosis, and can also correct protein metabolism disorders.