Advantages:
There is a complete production line. Stable and high-quality raw material sources. Mature and stable production process. The product solvent residue is qualified. A variety of product specifications are available. It can be stored for a long time in a cool, dry place and sealed away from light.
Product function and use
1. Anti-pathogenic microorganism effect
Animal experiments show that both andrographolide and neoandrographolide can inhibit and delay the increase in body temperature caused by pneumococci or hemolytic B streptococci, but andrographolide has a stronger effect than neoandrographolide. In vitro experiments show that Andrographis paniculata has certain anti-HIV effects.
2.Antipyretic effect
Andrographolide has varying degrees of antipyretic effects on endotoxin fever, pneumococci or hemolytic streptococci in rabbits. The antipyretic effects of Andrographis paniculata A, B, C, and D on rabbits with fever caused by typhoid and paratyphoid vaccines or rats with fever caused by gradually weakened.
3.Anti-inflammatory effect
Andrographis paniculata A, B, C and D all have anti-inflammatory effects to varying degrees. Oral administration at 1g/kg can inhibit the increase in capillary permeability of the skin or abdominal cavity of mice caused by xylene or acetic acid, and reduce the effects of croton oil in Selye granulation cysts. Causes acute exudate volume, but has no significant effect on granulation tissue hyperplasia. It can inhibit the development of egg white-induced paw swelling in rats, but the effect disappears after adrenal gland removal. Dingsu has the strongest anti-inflammatory effect, followed by C, A and B.
4.Effects on the body's immune function
There are reports that Andrographis paniculata may have an effect on certain aspects of cellular immunity. Its water decoction can improve the ability of human leukocytes to phagocytose Staphylococcus aureus in vitro. Oral administration of Andrographis paniculata can enhance the delayed skin hypersensitivity reaction caused by old tuberculin. Andrographis paniculata preparation Xinyandeping (containing esters and ketones) can increase the serum lysozyme level in mice and enhance the phagocytic capacity of peritoneal macrophages and neutrophils. Continuous administration of andrographolide sulfonate to rabbits or mice can significantly increase the phagocytic ability of peripheral blood phagocytes against pneumococci or Staphylococcus aureus. Andrographis A injection and Xiyanping injection can also enhance the function of phagocytes. . Dehydrated andrographolide succinate half-ester also has an inhibitory effect on delayed-type hypersensitivity in mice induced.
5.Anti-fertility effect
Andrographis paniculata has a significant effect on terminating pregnancy. Oral administration of Andrographis paniculata can cause contraception in mice and abortion in pregnant rabbits. Intraperitoneal injection of water decoction has a significant halting effect on different stages of implantation, early pregnancy, middle pregnancy, and late pregnancy in mice. Intramuscular injection, subcutaneous injection, oral administration, intraperitoneal injection, intravenous injection and intrauterine injection can all produce anti-early pregnancy effects, among which intraperitoneal, intravenous and intrauterine injection have the best effect. If exogenous progesterone or luteinizing hormone-releasing hormone (LH-RH) is injected with Andrographis paniculata at the same time, miscarriage can be prevented. This suggests that Andrographis paniculata may have the effect of antagonizing progesterone in the body, thereby causing miscarriage. Studies have shown that some semi-synthetic derivatives of andrographolide also have varying degrees of anti-early pregnancy effects and are a new contraceptive drug worthy of further study. The drug has a significant impact on placental trophoblast cells, causing placental villi to shrink and reduce cell number. decrease, syncytial cells and Langerhans cells disappear, interstitial edema and bleeding.
6.Choleretic and hepatoprotective effect
Andrographis paniculata has a choleretic effect on rats, increases liver weight, and shortens sleep time caused by cyclohexobarbital sodium. Pre-administration of andrographolide can antagonize the hepatotoxic effects caused by carbon tetrachloride, D-galactosamine and acetamidophenol, and can significantly reduce the levels of SGPT, SGOT, SALP and HTG respectively. There are reports that the methanol extract of Andrographis paniculata is toxic and can promote the death of rats with liver damage.
7.Anti-tumor effect
Dehydrated andrographolide succinate half-ester has a certain inhibitory effect on W256 transplanted tumors. Arginine double salt (orthosuccinic acid for short) is made from dehydrated andrographolide disuccinate half ester potassium hydrogen, which has an inhibitory effect on tumor cells regardless of large, medium or small doses, and the effect increases with the increase of the dose. The anti-tumor effect is reliable and stable. In vitro experiments have shown that Andrographis paniculata has an inhibitory effect on DNA synthesis in cultured breast cancer cells. Andrographolide can increase adrenocortical function, and Andrographis A, B, C and D can cause thymus atrophy in young mice at larger doses.
8.Toxic side effect
Clinical application of this product has less toxic and side effects. The LD50 of Andrographis paniculata extract administered to mice is 13.19g/kg (calculated as andrographolide)
Storage :
Store in a cool, dry, dark, and high-temperature place.
Packaging :
Negotiate or use double layer plastic bags internally, 1kg aluminum foil bags, 25kg drum.
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